Modification of the crystallographic structure of olanzapine during solvation by PALS and X-ray diffraction methods

摘要

Two selected solvents were incorporated into the olanzapine structure. Molecules located inside the voids in the structure caused the changing of the o-Ps lifetime and intensity. After removing the n-butanol·H_2O molecules, the materials returned to its initial structure. Creating the complex with the methanol·H_2O leads to the change of the crystallographic structure of the olanzapine.