Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Moessbauer spectroscopy

摘要

Fe_3O_4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Moessbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Moessbauer data confirms that superparamagnetic nanoparticles Fe_3O_4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.