Moessbauer study of exogenous iron redistribution between the brain and the liver after administration of ~(57)Fe_3O_4 ferrofluid in the ventricle of the rat brain

摘要

Iron clearance pathways after the injection of ~(57)Fe_3O_4-based ferrofluid into the brain ventricles were studied histologically and by Moessbauer spectroscopy. It was found that the dextran coated initial na-nobeads of the ferrofluid disintegrated in the brain into separate superparamagnetic nanoparticles within a week after the injection. The exogenous iron completely exited all ventricular cavities of the brain within a week after the injection but remained in the white matter for months. Kupffer cells with the exogenous iron appeared in the rat liver 2 hours after the injection. Their concentration reached its maximum on the third day and dropped to zero within a week. The exogenous iron appeared in the spleen a week after the injection and remained in the spleen for months.