Drug Release from a pH/Temperature Sensitive Hydrogel Bead of Poly(Lysine Methyl Ester-Diacetoxy Tartaric Acid) and Sodium Alginate

摘要

In this study, a pH/temperature sensitive polymeric hydrogel from poly (lysine methyl ester-diacetoxy tartaric acid) and sodium alginate (PLMD-SA) was prepared via the condensation polymerization. Using indomethacin as the model drug, the controlled drug-release from the resulting pH/temperature sensitive PLMD-SA was evaluated as functions of pH, PLMD content and temperature by UV spectrophotometer. It was found that the release amount of indomethacin in pH=7.4 phosphate buffer solution(PBS) was evidently higher than in pH=2.3 PBS.