Study of porous hydroxyapatite / Chitosan bioceramics for bone implantation

摘要

Hydroxyapatite/Chitosan bioceramics were fabricated by combining in-situ chemical synthesis and freeze drying method, using (NH_4)_2HPO_4, Ca(NO_3)_2-4H_2O, and chitosan(CS) as raw materials. The effect of freezing temperatures, solid loading and freeze-drying time on microstructures of hydroxyapatite/Chitosan bioceramics was studied. The microstructures of the fabricated porous bioceramics were investigated by means of Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The results showed that the hydroxyapatite/Chitosan bioceramics have interconnected porous structures from several microns to 200um, more suitable to bone tissue implantation. In addition, the porous structures are affected by freezing temperature.