ADULT STEM CELLS FOR TREATMENT OF OA IN THE DOG: DATA TO ANDFROM THE CLINIC

摘要

Adult stem cells in veterinary medicine can be derived from adipose tissue or from bone marrow. In small animal veterinary medicine stem cells are more commonly collected from adipose tissue but my opinion is that bone marrow-derived cells remain a perfectly reasonable option. There are key species differences and this is one difference between the canine and equine world. In horses, adult stem cells are usually collected from bone marrow because it can be performed in the standing horse and the BM provides a better source of cells than fat. In dogs, adipose-derived stem cells (ASC) are usually collected from the falciform ligament but can also be collected from any fat deposit such as just caudal to the shoulder or from the inguinal region. Although the data is not definitive; recent investigations have suggested that cell harvest from the falciform ligament generally yields the largest, most predictable amount of cells. Adipose-derived cells appear to have a similar potential for differentiationinto bone, cartilage, adipose, and fibrous tissues as bone marrow derived cells. This multipotency is a key component to calling a cell a "stem cell" and is something we, and others, have been able to demonstrate from fat and BM derived cells in the dogand horse.