A Self-assembled Peptide-based Adjuvant Eliciting Strong Antibody Responses with Minimal Inflammation

摘要

OVA-Q11 induced a stronger and more rapid antibody response in mice than Alum-OVA, with modest T cell responses and without inducing local inflammation. The discordance between the minimal inflammatory and T cell responses and the robust T-dependent antibody response suggests that mechanism of OVA-antigen presentation by Q11 is distinct from that of Alum. To identify the mechanism, future work will include using fluorescently-labeled OVA-Q11 or OVA-Alum to identify the sequence of uptake by cells at the injection site and in the draining lymph node. Our observations suggest that Q11-based systems may eventually provide a new route to safe and potent vaccines without undesired inflammation.