Effect of konjac gfucomannan content on the structure and properties of Sodium hyaluronate/chitosan/konjaG glucomannan composite films

摘要

Unsoluble composite films have been prepared by blending konjac glucomannan(KGM)/ sodium hyaluronate(SH) aqueous solution with chitosan(CS) solution in acetate solution, filtering, deaerating, tape casting, drying at 55°C for 8h and crosslinking with the aid of sodium hydroxide solution for 2h. The effect of KGM content on the structure and properties of SH/CS/KGM composite films were investigated. It was indicated that the KGM can significantly improve the tensile strength (σb,) and breaking elongation (εb) of the SH/CS composite films, and the tensile strength (σb,) and breaking elongation (εb) increased with the increase of KGM content in composite films. It was revealed by IR and X-ray analysis that the crystallinity of composite films decreased with the increase of KGM content and the composite films was mainly amorphous. It was indicated via scanning electron microscopy(SEM) and bone marrow mesenchymal stem cell experiments that the films could support the growth of cells and were non-toxicity and good biocompatibility.