Synthesis, Characterisation and Antibacterial Studies of 1,2-Bis(N'-2,3 and 4-methoxybenzoylthioureido)-4-nitrobenzene

摘要

A series of bisthiourea ligands, namely 1,2-bis(N'-2-methoxybenzoylthioureido)-4-nitrobenzene (T1), l,2-bis(N'-3-methoxybenzoylthioureido)-4-nitrobenzene (T2) and 1,2-bis(N'-4-memoxybenzoylthioureido)-4-nitrobenzene (T3) have been successfully synthesised. The reaction was performed using 2:1 ratio. The structures of the ligands have been characterised by elemental analysis (CHNS), IR spectroscopy, ~1H Nuclear Magnetic Resonance (NMR) and melting point determination method. The thiourea ligands were screened for their antibacterial activity using disc diffusion method against Gram-positive bacteria {Bacillus subtillis ATCC 6633, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393) and Gram-negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 10145, and Shigella sonnei ATCC 9290). The efficacy of the compounds against Gram-positive bacteria is higher than Gram-negative bacteria.