Study on the Preparation Process of Salicylic Acid Liposome Gel

摘要

Objective To optimize the preparation technology of salicylic acid liposome gel. Method Salicylic acid liposome was prepared with reverse evaporating method, and liposome gel was prepared using carbomer-940 as matrix. The encapsulation efficiency and leaking percentage of salicylic acid liposome was determined with centrifugal method, and the preparation technology of liposome gel was optimized with orthogonal test. Results The encapsulation efficiency of salicylic acid liposome was 75.86％, leaking percentage was 1.37％. The optimal preparation technology of liposome gel were carbomer 3g, glycerol 15g, mixing temperature 40°C, mixing time 15min. Conclusion Reverse evaporating method was a good method to prepare salicylic acid liposome with higher encapsulation efficiency and better stability. The optimized preparation process of liposome gel was desirable, and the characteristics of product was stable and uniform.