Effect of antibiotics on the exo-poiysaccharides and triterpenoids biosynthesis by the submerged culture of Ganoderma Lucidum

摘要

Effects of antibiotics addition on the mycelia growth and production of exo-polysaccharides (EPS) and triterpenoids in the submerged culture of Ganoderma Lucidum were studied. It was proved that adding amphotericin and terbinafme in favor of improving the excreting of EPS and triterpenoids, especially amphotericin can obviously improve the production of EPS and triterpenoids of Ganoderma lucidum. The results showed that when a level of 10 μg/mL amphotericin was added after 72 h culture, the EPS and triterpenoids reached a maximum of 3.2 g/L and 1.5 g/L, that was 1.45-fold and 1.36-fold compared to that of control, and the biomass of Ganoderma lucidum reduced to 9.85 g/L, that was 88% compared to that of control.