Synthesis, Structure and Gastric H~+/K~+-ATPase Inhibitory Activities of Bisabolonafone Hydrazone Carboxamides

机译：合成，结构和胃H〜+ / k〜+ -ATP酶抑制酶抑制作用碳酰胺碳甲酰胺

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Five novel bisabolonalone hydrazone carboxamides were synthesized as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. All of the compounds possessed the better H~+/K~+-ATPase inhibitory activity than the commercial omeprazole with the IC_(50) of 18-68 μM in vitro. These compounds could be potentially use for the treatment of ulcer related diseases.

机译：将五种新的Bisabolonalone腙甲酰胺合成为潜在的抗溃疡剂。它们的结构以NMR，IR和ESI-MS为特征。所有化合物都具有比商业奥美拉唑在体外18-68μm的IC_（50）的商业奥美拉唑更好的H〜+ / K〜+ + -ATP酶抑制活性。这些化合物可能用于治疗溃疡相关疾病。

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《International Conference on Chemical Engineering and Advanced Materials》|2013年||共4页
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Lei Jin; Lei Chen; Huajun Luo;
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中图分类 TB3-532;
关键词
Bisabolangelone; H~+/K~+-ATPase inhibitor; synthesis; hydrazone carboxamide;

机译：Bisabolangelone;H〜+ / K〜+ -Atpase抑制剂;合成;腙羧酰胺;

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4. Synthesis, Structure and Gastric H~+/K~+-ATPase Inhibitory Activities of Bisabolonafone Hydrazone Carboxamides [C] . Lei Jin, Lei Chen, Huajun Luo International Conference on Chemical Engineering and Advanced Materials . 2013

机译：合成，结构和胃H〜+ / k〜+ -ATP酶抑制酶抑制作用碳酰胺碳甲酰胺
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Synthesis, Structure and Gastric H~+/K~+-ATPase Inhibitory Activities of Bisabolonafone Hydrazone Carboxamides

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