Effect of geldanamycinon the glioma cell invasion induced by hepatocyte growth factor

摘要

To investigate the effect of geldanamycin (GDM) on theinvasion abilityofglioma cell induced by hepatocyte growth factor (HGF). Malignant glioma cell lineU251-MG and U87-MG were cultured' and the capability of cell invasion was detected using a Transwell culture system. HGF significantly promoted the invasion ability of both U251-MG and U87-MG cells as compared with the normal control (NC) (P<0.05). Forty eight hours after GDMtreatment, the invasive growth of glioma cells was significantly decreased as compared with either NC or HGF group (P<0.05). When cells were exposed to GDM plus HGF for 48 h, the cell invasion capability was greatly reduced as compared with either NC or HGF group (P<0.05).The number of invaded cells in GDM plus HGF group was similar to that of GDM group.GDM can inhibit the invasion ability of glioma cells induced by HGF.