A development of an non-invasive optical sensor for determining nitric oxide changes after arm-cuff occlusion

摘要

This study is the invention of the non-invasive optical sensor for measuring the change of nitric oxide. The sensor composes of light emitting diode with a wavelength at 525 nm, photo diode having sensitivity in the range of 400 to 1100 nm, measuring circuit that could transfer data to personal computer for analyzing and displaying result in real time. For preliminary test, the system was used to measure a standard nitric oxide derivative solution concentration of 0.125-1.000 mM. Further study was monitored the changes of nitric oxide level in fingertips of 25 volunteers after using upper-arm occlusion technique and comparing between the results of perfusion rate in 5 volunteers. Therefore, this optical sensor for measuring the change of nitric oxide may be used to examine the efficacy of endothelial function in the near future, particular via non-invasive technique.