Fabrication and characterization of poly l-lactic acid/modified nano-hydroxyapatite composite fibrous scaffold

摘要

Nano-hydroxyapatite were modified with biocompatible polyethylene glycol (PEG) by surface coating, so modified nano-hydroxyapatite particles (modified nano-HA) were prepared. A homogeneous solution was obtained by dispersing the modified nano-HA into poly l-lactic acid (PLLA) solution. Composite fibrous scaffold was fabricated via electrostatic spinning method with the homogeneous solution. The composite fibrous scaffold was characterized by SEM, TEM and XRD techniques. The characterization results showed that the surface morphology of the composite fibrous scaffold was smooth, modified nano-HA was dispersed in PLLA homogeneously, the hydrophilicity of composite fibrous scaffold were increased obviously. Adipose-derived stem cells (ADSCs) proliferating in the fibrous scaffold were investigated by using laser scanning confocal microscope observation.