Using spectral photoacoustic imaging (sPAI) to estimate oxygen saturation of tissue at depth suffers frominaccuracies due to the unknown optical absorption and scattering properties of tissue. Because of the highscattering and absorption of light by tissue, the estimation of concentrations of Hb and HbO2 from the measuredphotoacoustic (PA) signal intensity can be erroneous. Simulation of wavelength-dependent light transport intissue can help to estimate the local fluence distribution within the tissue. In this work, a Monte Carlo simulationhas been implemented to simulate the fluence distribution in placental tissue. We obtained sPAI images of exvivo human placental tissue and demonstrate improved estimations of hemoglobin oxygen saturation by usinga fluence correction derived from the Monte Carlo simulation. The results show that with simulation correction,the oxygen saturation value is 12.61±3% which is closer to the value 6.8% directly measured from ex vivohuman placenta using invasive oxygen probe.
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