SERS spectroscopy, electrical recording and intracellular injection in neuronal networks with 3D plasmonic nanoantennas.

摘要

We developed a platform based on 3D plasmonic nanoantennas able to perform different functions with applications in the biological research area. In particular it will be shown how the peculiar geometry of the system plays a fundamental role, leading to a tight interaction with the cellular membrane. Such configuration allows on one side the investigation of extracellular features through enhanced vibrational spectroscopy and electrical recording, and on the other the possibility of intracellular injection by optoporation. In this regard it will be demonstrated how the characteristics of the laser pulse used for exciting the antenna establish the kind of involved phenomena. A dependence of these properties on the metal coating the antenna will be also shown.