Minimal-Dose Cancer Chemotherapy: Anti-Cancer Drugs Loaded Nanodevices towards Time, Site Organ-Specific Releases for Development of Personalized Nanomedicine

摘要

An attempt to design a site-directed, organ-targeting, time-maneuvered, controlled drug delivery nanodevice was undertaken. The anti-cancer drug methotrexate loaded nanovesicles of human serum protein albumin, surface-functionalized with tumor-affinity protein avidin, for treatment of human mammary gland carcinoma were prepared. The formulation was designed for a minimum dose requirement with predictable span of delivery and fixed-frequency of administration towards a goal for developing personalized nanomedicine suitable for individually defined medication requirements.