RELEVANCE OF DIFFERENT ANTIBODY DETECTION METHODS FOR PREDICTION OF ANTIBODY MEDIATED REJECTION OF DECEASED DONOR KIDNEY ALLOGRAFTS

摘要

Modern donor-specific antibody detection techniques now allow unparalleled sensitivity in the detection of anti-HLA antibodies. However, a few pertinent questions arise. Should the definition of a sensitized patient expand or depend on the threshold of the detected antibody? And if so, should this occur despite evidence that the antibody is not cytotoxic? To answer these questions, we analyzed the predictive value of DSA detected with solid-phase assay (SPA) and flow cytometry in a cohort of recipients of deceased donor kidneys (N=325).