IMPACT OF HLA ANTIBODY AND DESENSITIZATION THERAPY IN LUNG TRANSPLANTATION

摘要

The presence of pretransplant third party HLA specific antibodies or the development of post-transplant de novo HLA specific antibodies has been associated with acute and chronic posttransplant immune complications, bronchiolitis obliterans syndrome (BOS) and decreased survival in lung transplantation. To reduce the incidence and severity of the posttransplant immune complications, desensitization protocols utilizing IVIG with or without plasmapheresis have been used at our center for sensitized recipients with third party (non donor) HLA specific antibodies or as rescue intervention for those who developed posttransplant de novo donor specific antibody (DSA).The aim of our study was to determine if the desensitization therapy assuaged the negative impact of HLA specific antibodies.