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Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro

机译:循环拉伸对正常人肺动脉内皮细胞早期反应基因表达的影响

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The effects of cyclic stretch (within 30 min) on the expressions of early response genes in normal human pulmonary artery endothelial cells (HPAEC) were investigated using an in vitro stretch system. The investigated early response genes were early growth response gene 1 (Egr1), heat-shock protein 4 (Hspa4), PTGS4 (cox2) and the inflammatory cytokines interleukin (IL)-1, IL-6 and IL-8. The genes of Egr1 and PTGS2 were upregulated at early stages by cycle stretch.
机译:使用体外拉伸系统研究了循环拉伸(30分钟内)对正常人体肺动脉内皮细胞(HPAEC)中早期反应基因表达的影响。所研究的早期反应基因是早期生长响应基因1(EGR1),热休克蛋白4(HSPA4),PTGS4(COX2)和炎性细胞因子白细胞介素(IL)-1,IL-6和IL-8。通过循环拉伸在早期阶段上调EGR1和PTGS2的基因。

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