The calcium-sensing receptor (CaSR) is a class 3 GPCR that is activated not only by extracellular Ca~(2+) ions (Ca~(2+)_o), but also allosterically by type II calcimimetics, including cinacalcet, and L-amino acids. The CaSR has eight recognised N-linked glycosylation sites in the extracellular domain and disruption of groups of five sites reduces surface expression by 50 -90% with attendant functional impairment. However, the roles of individual N-glycosylation sites in expression and function are unknown.
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