首页> 外文会议>International forum on post-genome technologies >ASSOCIATION OF MICRORNA-210 AND EPHREV A3 EXPRESSION WITH RENAL ISCHEMIA/REPERFUSION INJURY IN MICE
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ASSOCIATION OF MICRORNA-210 AND EPHREV A3 EXPRESSION WITH RENAL ISCHEMIA/REPERFUSION INJURY IN MICE

机译:MicroRNA-210和Ephrev A3表达与小鼠肾缺血/再灌注损伤的表达

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MicroRNAs are a group of small non-coding RNAs with modulator activity of gene expressioa Recent studies have uncovered a profound role of microRNAs in renal diseases. This study aimed to investigate a potential relationship between MicroRNA- 210 (miR - 210) expression and renal ischemia/reperfusion injury in mice Quantitative RT-PCR analysis showed that miR - 210 expression levels were greatly up-regulated in the renals after 45 min ischemia followed by 120 min reperfusion when compared to sham controls. Immunohistochemical staining analysis also showed that miRNA targeted RNA, ephrin A3 expression levels were greatly down-regulated compared to sham controls. Thus, we conclude that renal ischemia/reperfusion injury might be another form of renal disease that is associated with alteration in miR - 210 expressioa
机译:MicroRNA是一组小型非编码RNA,具有基因的调节剂活性,最近的研究已经发现MicroRNA在肾病中的深刻作用。本研究旨在探讨MicroRNA-210(miR - 210)表达和肾缺血/再灌注损伤的潜在关系RT-PCR分析表明,在45分钟缺血后,MIR - 210表达水平在肾脏中大大上调与假对照相比,随后120分钟再灌注。免疫组织化学染色分析还表明,与假对照相比,MiRNA靶向RNA,Ephrin A3表达水平大大降低了调节。因此,我们得出结论,肾缺血/再灌注损伤可能是另一种形式的肾病,与miR - 210表达的改变有关

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