Design of Phosphotyrosine Mimetics Targeting the Src Homology 2 Domain-Containing Phosphatase 1 (SHP-1) Non-Receptor Binding Site

摘要

Protein tyrosine phosphorylation is a ubiquitous signaling mechanism that is regulated by an intricate balance between the action of kinases and phosphatases. Protein tyrosine kinases (PTKs) phosphorylate cellular substrates and the protein tyrosine phosphatases (PTPs) act by removing these phosphate groups through hydrolysis. The Src homology 2 domain-containing phosphatase 1 (SHP-1) is a classical non-receptor PTP containing a single tandem catalytic domain.