Studying the evolution of codon context in conserved gene sequences

摘要

- Several studies demonstrate that the codon context is an important characteristic in gene primary structure that modulates the translation of mRNA. To better understand these features we developed a software package that uses sequences of Open Reading Frames (ORFs) available in public databases and applies several statistic and visualization methodologies to unveil codon-context patterns, codon usage and others features. In this paper we describe a new method to study the evolution of codon contexts in conserved sequences between species. For this, we associate the codon-context statistic significance with BLASTP and ClustalW metrics. With these results it is possible to reveal important rules in the evolution of codon-pair context.