首页> 外国专利> Modified gene encoding a rna, protein, polypeptide or peptide, vector, methods for controlling the production of a protein, polypeptide or peptide from a gene, to modify a gene, to remove a 5'-cap structure and / or a 3'-pulley tail of a pre-mRNA or mRNA transcribed from a gene, for controlled production of a protein, polypeptide or peptide within a cell, of evolution and in vitro selection for the production of a ligand-bound RNA sequence of evolution and in vitro selection for the production of a ligand-dependent self-cleavable RNA sequence, synthetic DNA molecule, combination of ligand and modified gene, dna, and ligand-dependent self-cleaving synthetic RNA molecule

Modified gene encoding a rna, protein, polypeptide or peptide, vector, methods for controlling the production of a protein, polypeptide or peptide from a gene, to modify a gene, to remove a 5'-cap structure and / or a 3'-pulley tail of a pre-mRNA or mRNA transcribed from a gene, for controlled production of a protein, polypeptide or peptide within a cell, of evolution and in vitro selection for the production of a ligand-bound RNA sequence of evolution and in vitro selection for the production of a ligand-dependent self-cleavable RNA sequence, synthetic DNA molecule, combination of ligand and modified gene, dna, and ligand-dependent self-cleaving synthetic RNA molecule

机译:编码RNA,蛋白质,多肽或肽的修饰基因,载体,控制基因中蛋白质,多肽或肽的产生,修饰基因,去除5'-帽结构和/或3'-的方法从基因转录的前mRNA或mRNA的滑轮尾,用于控制细胞内蛋白质,多肽或肽的产生,进化和体外选择,以产生配体结合的RNA进化和体外选择序列用于生产依赖配体的自切割RNA序列,合成DNA分子,配体和修饰基因的组合,dna和依赖配体的自切割合成RNA分子

摘要

"MODIFIED GENE THAT CODES AN RNA, PROTEIN, POLYPEPTIDE OR PEPTIDE, VECTOR, METHODS TO CONTROL THE PRODUCTION OF A PROTEIN, POLYPEPTIDE OR PEPTIDE FROM A GENE, TO MODIFY A GENE, TO REMOVE A STRUCTURE OR 5 / A 3'-PULLEY TAIL FROM A PREMNA OR MRNA TRANSCRIBED FROM A GENE, FOR CONTROLLED PRODUCTION OF A PROTEIN, POLYPEPTIDE OR PEPTIDE WITHIN A CELL, EVOLUTION AND IN VITRO SELECTION FOR THE PRODUCTION OF A RNA LIGUE SEQUENCE AND IN VITRO EVOLUTION AND SELECTION FOR THE PRODUCTION OF A SELF-CLIVABLE RNA SEQUENCE DEPENDENT ON BINDER, SYNTHETIC DNA MOLECULE, COMBINATION OF BINDER AND MODIFIED GENE, DNA, AND, RNA AUTO-LENDANT SYNTHETIC MOLECULE. This invention relates to the control of protein synthesis from an mRNA sequence (activation or repression) by inserting a sequence into an untranslated region (RTU) of a gene that confers conditional self-cleavage to the transcribed RNA.
机译:“编码RNA,蛋白质,多肽或肽,矢量的修饰基因,控制从基因中生产蛋白质,多肽或肽,修饰基因,去除结构或5/3'滑轮尾巴的方法用于从细胞中产生蛋白质,多肽或肽的受控产物的premna或mRNA的进化,体外选择,RNA序列的产生以及体外选择和自身产生的选择结合剂,合成的DNA分子,结合的结合剂和修饰的基因,DNA和RNA自体合成分子的合适的RNA序列技术领域本发明涉及通过插入mRNA序列来控制mRNA序列的蛋白质合成(激活或抑制)。序列被赋予一个基因的非翻译区(RTU),该基因可对转录的RNA进行条件性自我切割。

著录项

  • 公开/公告号BR0014632A

    专利类型

  • 公开/公告日2002-06-18

    原文格式PDF

  • 申请/专利权人 AVENTIS PHARMA S.A.;

    申请/专利号BR20000014632

  • 申请日2000-10-13

  • 分类号C12N15/63;C12N15/67;C12N9/00;C12N15/10;C12Q1/68;

  • 国家 BR

  • 入库时间 2022-08-22 00:46:08

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