Novel Methods for the Separation of Optical Isomers

摘要

Recent developments in the field of racemate resolution has been reviewed and illustrated with examples. The excellent results achieved by the novel pH-controlled crystallization of diastereoisomeric salts, application of derivative resolving agents, complex forming resolution of chiral alcohols with O,O'-dibenzoyltartaric acid, enzymatic resolutions and dynamic kinetic resolutions demonstrate that the synthesis of racemic mixtures followed by optical resolution of the racemate represent nowadays an environmentally benign and economic alternative for preparation single enantiomers.