process for separation of the two optical isomers of 1 - (o - methoxyphenoxy) - 3 - isopropylamino - propan3 - oil, received optical isomers and pharmaceutical compositions which contain the linksdrehende isomer.

摘要

A process for the separation of moprolol having formula (I) into its two optical antipodes, by salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate sart of (-)moprolol with a base so as to separate the levorotatory isomer of crystalline moprolol, which finally undergoes a purification. …??Also a pharmaceutical composition containing said levorotatory isomer of …CHEM…