Chemically Modified Poly(Acrylic Acid) Monolayers in Alumina Nanoporous Membranes for Cancer Detection

摘要

]n this paper we have developed one of the key building blocks of the clinical proteomics test technology. This building block is a nanostructure that enables the confinement of protein biomolecules based on size-matched trapping. The prototype system is a nanoporous alumina membrane that is fabricated using a standard two-step electrochemical anodization process. We have chemically modified these membranes with poly(acrylic acid) to understand the effects of this chemical modification on the protein detection sensitivity. We plan on evaluating this prototype system in identifying cancer markers for early breast cancer detection to experimentally evaluate the effect of nanoscale-confined spaces on protein biomarker detection.