A generic model of overall heart geometry for model based studies of electrical, mechanical, and ion-kinetics aspects of the heart

摘要

A hierarchical set of tricubic deformations is used to map generic coordinates to real world coordinates. This provides a unifying framework to compare and combine different computational models. Large-scale cellular models can now use intramural fiber orientation measured with diffusion tensor imaging. Estimated activation times of the heart can be used to compute contraction and to determine how that in turn affects the surface ECG. These computations all use different models, but they can all use the same generic coordinates.