Mathematical model for change in size distribution of baculovirusinfected Sf-9 insect cells

摘要

Sf-9 insect cells were examined for size before and after baculovirus infection. The distribution of the diameter of uninfected Sf-9 insect cells was described by the normal distribution function with the mean diameter and standard deviation of 18.5±1.5 μm. After virus infection, the cells grew in size almost linearly with time for about 48 h to give a steady mean diameter 1.45 times larger than that of uninfected cells. In addition, the distribution began to broaden at around 6 h-post infection and eventually had standard deviation twice as large as that of uninfected cells. A mathematical model was developed to simulate the size distribution of virus-infected Sf-9 insect cells at any given time after viral infection.