Study on the preparation of hydroxycamptothecin semisolid lipid nanoparticles by orthogonal design

摘要

Objective: To prepare hydroxycamptothecin semisolid lipid nanoparticles (HCPT-SSLN). Methods: Based on the single-factor experiment, the HCPT-SSLN was prepared by using orthogonal design for optimization of formulation and technology. Then the obtained SSLN was also evaluated. Results: The mean particle size of the prepared HCPT-SSLN was 130.5nm, Polydispersity Index (PI) was 0.18, drag loading (DL) was 2.51%, entrapment efficiency (EE) was 79.19%, ζ potential was -33.1mV; Placed at 4°C for 6 months, the appearance, particle size and entrapment efficiency of SSLN were all stable. Conclusion: The HCPT-SSLN has high entrapment efficiency and drug loading, uniform particle size, good stability, which provides an extensive prospect for clinical application of HCPT.