Procedure for the preparation of lipid nanoparticles, and lipid nanoparticles with brain macrophages as target cells (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the preparation of lipid nanoparticles, and lipid nanoparticles with brain macrophages as target cells. The invention relates to a process for producing lipid nanoparticles especially directed against perivascular and meningeal brain macrophages, which includes the addition of a mannose derivative in its lipid layer as a functional component that favors interaction with the plasma membrane of the target cells. The functionalization of the lipid nanoparticles is carried out in an intermediate stage of the process and by means of a direct reaction in which a coupling agent is not needed, avoiding the use of toxic agents. The invention also relates to the multilamellar lipid nanoparticles that are obtained by means of this method, whose nucleus, especially dense, includes a nucleic acid with therapeutic interest and its applications against neurological/neurodegenerative and/or psychiatric pathologies. (Machine-translation by Google Translate, not legally binding)