Synthesis and Biological Activities of N-( 4-SubstItuted-phenyl) -N'- (1 '-beta- D-glucopyranosyl) - thiourea

摘要

Six N-(4-substituted-phenyl)-N'-( 2 , 3', 4', 6'-tetra~Oacetyl-beta-D-glucopyranosyl)-thioureas(4)were synthesized by condensation of 4-substituted-anilines(2)with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate(3)in ethanol under reflux,respectively,and also six N-(4-substituted-phenyl]-N'-(l'-beta-D-glucopyranosyl)-thioureas(5)after deacetylation. Their structures were confirmed by IR,~1 H NMR, ESI-MS spectral data and elemental analyses. The biological activities of thecompounds were investigated.