Pilot in vivo animal study of bone regeneration by fractional Er: YAG-laser

摘要

The histological structure of the rabbit parietal bone during its regeneration after fractional Er: YAG-laser (λ=2.94μm) treatment was investigated by hematoxylin and eosin (H&E) stain. In 48 days after fractional laser treatment, bone-samples contained microcavities and fragments of necrotic tissue with empty cellular lacuna and coagulated protein of bone matrix. In this case, necrotic lesions appeared around the periphery of microcavities created by laser radiation. Fragmentation of detrital mass and partial substitution of microcavities with fatty bone marrow were observed in bone-samples in 100 days after fractional laser treatment, in contrast to the earlier period. Partial filling of microcavities edges by fibrous tissue with presence of osteoblasts on their inner surface was observed in 100 days also, that indicates regenerative processes in the bone.