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Scalable Magnetoresistive Biochips For Biomolecular recognition

机译:用于生物分子识别的可缩放磁阻生物芯片

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The last few years have witnessed the development of magnetoresistive chips for use in biological assays 1, 2. In these assays, target biomolecules are labelled with nano- or micrometer-sized magnetic particles and are recognized by biomolecular probes immobilized over sensing sites. The detection of biomolecular recognition between probes and targets (e.g. DNA hybridization or antibody-antigen interaction) is accomplished by sensing the stray magnetic fields created by the labels using magnetoresistive sensors. These transducers change their electrical resistance in the presence of a magnetic field and are typically used in read-heads of hard-disk drives.
机译:过去几年目睹了磁阻芯片的开发,用于生物测定1,2。在这些测定中,靶生物分子用纳米或微米尺寸的磁性颗粒标记,并通过固定在传感位点上固定的生物分子探针识别。通过使用磁阻传感器感测由标签产生的杂散磁场来实现探针和靶标之间的生物分子识别(例如DNA杂交或抗体 - 抗原相互作用)。这些换能器在磁场的存在下改变其电阻,并且通常用于硬盘驱动器的读取头。

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