Copper-mediated reactions of ethyl bromodifluoroacetate (1) as procedures for the synthesis of compounds containing a CF2 group are presented. The complex formed in the reaction of 1 in the presence of copper powder reacted with vinyl or aryl iodides to give cross-coupling products, with Michael acceptors to give 1,4-addition products and with unactivated olefins to give radical addition products. Some applications of these reactions for synthesis of fluorine analogues of bioactive compounds are presented. A novel reaction mediated by the Wilkinson catalyst will be also presented.
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