1,4-Addition reaction of ethyl bromodifluoroacetate to michael acceptors in the presence of copper powder improvement of the reaction using TMEDA as an additive

摘要

Reaction of ethyl bromodifluoroacetate with a variety of Michael acceptors was tremendously improved by the addition of TMEDA.Using this additive, 1,4-adducts were formed exclusively, and any 1,2-adducts or radical adducts were not obtained. THF or other low boiling solvents can be used as a solvent. This simplifies the work-up of the reaction effectively.