Free radicals in the pathogenesis of murine ischemic cardiomyopathy

机译：小鼠缺血性心肌病发病机制中的自由基

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The repetitive ischemia and reperfusion (I/R) has been postulated as an important mechanism in the pathogenesis of ventricular dysfunction in ischemic cardiomyopathy and myocardial hibernation. We developed a murine model of repetitive I/R which led to reversible fibrosis and ventricular dysfunction in free redical dependent fashion, resembling the pathomorphology of human hibernating myocardium. We suggest an important role for free radicals in the pathogenesis of ischemic cardiomyopathy.

机译：重复的缺血和再灌注（I / R）已被假定为缺血性心肌病和心肌冬眠的心室功能障碍发病机制的重要机制。我们开发了一种重复I / R的小鼠模型，其导致可逆纤维化和室心功能障碍，以自由的细节依赖性方式，类似于人类冬眠心肌的病理态。我们向缺血性心肌病发病机制中的自由基提出了重要作用。

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《Nordrhein-Westfa?lische Akademie der Wissenschaften》|2005年||共2页
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O. Dewald; N.G. Frangogiannis; R.R Bowler; J.D. Crap;
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2. Milk whey protein decreases oxygen free radical production in a murine model of chronic iron-overload cardiomyopathy. [J] . Bartfay WJ, Davis MT, Medves JM, The Canadian journal of cardiology . 2003,第10期

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3. Free Radicals and the Pathogenesis of Type 1 Diabetes: β-Cell Cytokine-Mediated Free Radical Generation Via Cyclooxygenase-2 [J] . Tahereh Tabatabaie, Angelica Vasquez-Weldon, Danny R. Moore, Diabetes . 2003,第8期

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4. Free radicals in the pathogenesis of murine ischemic cardiomyopathy [C] . O. Dewald, N.G. Frangogiannis, R.R Bowler, Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

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5. Free radical mediated injury in ischemic and reperfused canine gracilis muscle flaps [D] . Brisson, Brigitte Anne-Marie. 2000

机译：自由基介导的犬缺血性和再灌注犬肌皮瓣的损伤
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8. Urinary Molecular Determinants for the Prediction of Ischemic Anoxic Stress Pathology: Evaluation of Lipid Peroxides, Phenolic Acids and Generated Free Radical Compounds as Bioindicators of Stress. [R] . Shmukler, H. W., Polis, B. D., Soffer, E. 1979

机译：用于预测缺血缺氧应激病理学的尿分子决定因素：评价脂质过氧化物，酚酸和产生的自由基化合物作为应激的生物指示剂。

Free radicals in the pathogenesis of murine ischemic cardiomyopathy

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