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Structural Characterization of Water Soluble Derivatives of Cisplatin Drugs from Chelation with Chitosan

机译:用壳聚糖螯合螯合药物水溶性衍生物的结构特征

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We have been investigating the synthesis of potential drugs for the treatment of cancer. One focus is the synthesis of cisplatin derivatives with lowered toxicities in comparison to cisplatin itself. The eventual aim for most drug synthesis it the production of water soluble drugs since this typically contributes to the ease of administration along with other reasons. Even so, most drugs employed today in the public sector are not water soluble but rather are often soluble in other solvents, most commonly DMSO. The cisplatin derivatives made by us are not water soluble so recent efforts have aimed at the synthesis of water soluble products. In a sister article we have described the synthesis of cisplatin-like drugs from chitosan. Here we describe some of the structural characterization of these products.
机译:我们一直在研究潜在药物治疗癌症的合成。一个重点是与顺铂本身相比,单铂衍生物具有降低的毒性。大多数药物合成的最终目标是水溶性药物的生产,因为这通常有助于易于给药以及其他原因。即便如此,今天在公共部门的大多数药物都不是水溶性,而是常常可溶于其他溶剂,最常见的DMSO。美国制造的顺铂衍生物不是水溶性,因此最近的努力旨在合成水溶性产品。在姐妹文章中,我们已经描述了从壳聚糖的顺铂类药物的合成。在这里,我们描述了这些产品的一些结构特征。

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