Functionalized Nanoporous Molecular Sieves for Chromatographic Separations of Proteins

摘要

Protein, monoclonal antibody (MAb), and p-DNA purifications are of great importance in the evolving biopharmaceutical industry. The commercial production of these compounds as therapeutic drugs continues to be challenged by limitations in downstream purification techniques. Chromatography is an indispensable separation method for process-scale purifications of biomolecules. Overloaded chromatography is therefore the subject of intense basic research. Two issues of importance are the availability of highly selective adsorbents for the large variety of separations that are of commercial significance, and an incomplete understanding of the process of biomolecular adsorption/desorption.