Advances in the Synthesis and Characterization of Polypeptide-Based Hybrid Block Copolymers

摘要

Linear polystyrene-block-poly(Z-L-lysine) copolymers with a very narrow molecular weight distribution (polydispersity index < 1.03) could be obtained via the ring-opening polymerization of Z-L-lysine-N-carboxyanhydride using ω-(primary amino hydrochloride)-polystyrenes as macroinitiators in N,N-dimethylformamide as the solvent at 40-80°C. The block copolymer samples were analyzed by means of NMR, size exclusion chromatography, and analytical ultracentrifugation.