A model integrating the cerebellar granule neuron excitability and calcium signaling pathways

摘要

The activation of various intracellular biochemical pathways is influenced by the electroresponsiveness of the neuron. There exists a close and constant co-operation between the membrane-bound cellular functions and intracellular signaling. This work aims at integrating the biophysical and biochemical data available for the cultured cerebellar granule neuron. The models of calcium-protein kinase C signaling pathways are combined with the model of the granule neuron excitability. The latter model can be used to provide the realistic stimulus for the signaling pathway models. The integrated model makes it possible to explore the participation of intracellular mechanisms in the neuronal information processing.