STEREOSPECIFIC C-H BOND ACTIVATION FOR DEUTERIUM AND TRITIUM LABELING OF GLYCOCONJUGATES CONDUCTED IN ULTRASONIC AND MICROWAVE FIELDS

摘要

We have continued our development of a stereospecific 'H-"2H catalytic exchange technique using Raney? nickel catalysts in a heterogeneous reaction. This technique is facile, employs very mild reaction conditions and is tolerant of thermally sensitive (and many chemically sensitive) moieties. Since epimerization, racemization and degradation are absent, product isolation is generally quantitative. Our research efforts are directed towards understanding the subtleties, mechanistic implications and potential utility of this technique for selective 3H incorporation.