Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C-H bond activation

摘要

An efficient and facile deuterium labeling of sugars has been achieved in a completely regio-, chemo- and stereoselective manner using the Ru/C-H_2-D_2O combination via C-H bond activation assisted by the coordination of Ru to the oxygen atom of the sugar-hydroxyl groups.