Analysis of Halogenated Alkylphenolic Compounds in Environmental Samples by LC/MS and LC/MS/MS

摘要

The state-of-the-art in the LC-MS and LC-MS-MS analyses of halogenated alkylphenolic compounds formed during wastewater and drinking water chlorination is reviewed. Single stage LC-MS with ESI ionization showed limitations in the analysis of real-world samples, resulting from the presence of isobaric interferences when only deprotonated molecules are monitored. With collision-induced dissociation halogenated NPs and NPECs gave specific fragments formed by the cleavage of the alkyl moiety or by the loss of (ethoxy)carboxylic group, respectively. Characteristic pattern of isotopic doublet signals of these specific transitions coupled with formation of [Br]~- and [Cl]~- permitted unequivocal identification of halogenated alkylphenolic compounds in environmental samples. Limits of detection by LC-MS and LC-MS-MS were in the range of 10 and 1 ng/1, respectively.