Comparison of Raman and UV Spectroscopy for the in- Line Quantification of Active Ingredient in Pharmaceutical Semi-Solid and Liquid Formulations

摘要

In-line spectroscopic techniques are increasingly proposed as alternative methods for the quantification of active ingredients in pharmaceuticals. This is due to their advantages over the traditional methods, such as fast and non-destructive measurements without the need of sample pretreatment. One of these spectroscopic techniques is Raman, that is until now, mostly applied for solid dosage forms. UV spectroscopy is a widely used quantification technique, although less frequently implemented inside a process environment for in-line monitoring.