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THE EFFECT OF PROCESS PARAMETERS INCLUDING BLEND SHEARING AND COMPACTION PRESSURE ON PHARMACEUTICAL TABLET PROPERTIES

机译:工艺参数的效果包括对药片性能的混合剪切和压实压力

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The purpose of this study was to gain an understanding of the effects of process parameters on tablet properties in the case of blends with lubricants. Magnesium Stearate has been widely used as a lubricant in pharmaceutical formulations for the past 50 years. Different studies have been published to explain the effect of concentration levels of magnesium stearate on tablet and blend properties. However, as much is the concentration of magnesium stearate important, so is the amount of energy that goes into its blending with the excipients.
机译:本研究的目的是了解在用润滑剂混合的情况下对过程参数对片剂性能的影响。硬脂酸镁在过去50年中被广泛用作药物制剂中的润滑剂。已经公布了不同的研究以解释浓度水平硬脂酸镁对片剂和混合物性能的影响。然而,尽管如此,硬脂酸镁的浓度是重要的,所以能量与赋形剂共混的能量。

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