Process for the preparation of tablets from pharmaceutically active substances having unfavorable tabletting properties with a granulating liquid comprising microcrystalline cellulose.

摘要

Process for the preparation of tablets that can be well compressed and have good mechanical strength from ingredient (s) pharmaceutically active (s) having unfavorable tabletting properties by mixing the ingredient (s) pharmaceutically active (s) with vegetables conventional used in tabletting, preferably binding agent (s) binder (s) and / or agent (s) of filler and / or agent (s) and / or disintegration surfactant (s), granulating the mixture in the presence of a liquid granulation by a spray process by fluidization or mixing and tabletting the granules obtained using further carriers conventionally employed in tabletting, preferably lubricant (s) and / or agent (s) disintegrant (s) and / or fluxing (s) in wherein the granulating liquid is a suspension of 5-30% of microcrystalline cellulose, 90% of which has a particle size below 50 .mu.m, and ca ntidad microcrystalline cellulose refers to the final tablet mass, in water and / or ethanol and / or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.