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Preparation of tablets of pharmaceutically active substances with unfavorable tableting properties with a microcrystalline cellulose containing granulating liquid
Preparation of tablets of pharmaceutically active substances with unfavorable tableting properties with a microcrystalline cellulose containing granulating liquid
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机译:用含微晶纤维素的造粒液制备具有不利压片特性的药物活性物质片剂
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摘要
The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30 % of microcrystalline cellulose - 90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.
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